EN FR
EN FR


previous Previous | up Home | Next next


Section: New Software and Platforms

Angio-Analytics

Participants: T. Bastogne

Figure 1. Example of a skinfold chamber placed on a mouse skin
IMG/imageTB1.jpg

A software Angio-Analytics has been developed by J.-B. Tylcz, E. Djermoune and T. Bastogne. This tool allows the pharmacodynamic characterization of anti-vascular effects in anti-cancer treatments. It uses time series of in vivo images provided by intra-vital microscopy. Such in vivo images are obtained owing to skinfold chambers placed on mice skin, as illustrated in Fig. 1 . The automatized analysis is split up into two steps that were completely performed separately and manually before. The first steps corresponds to image processing to identify characteristics of the vascular network, as illustrated in Fig. 2 . The last step is the system identification of the pharmacodynamic response and the statistical analysis of the model parameters as shown in Fig. 3 and Fig. 4 . An article has been submitted to a journal (Biomedical Signal Processing and Control) and is currently in revision process. Moreover, the current version of the software has been registered to the Agence de Protection des Programmes.

Figure 2. Example of segmentation process on a control (left) and treated tumor (right) at day -7: manual segmentation (ROI) of cancerous tissues is done in yellow on step A, vessel segmentation is performed on step B (vessels are in white), step C presents the quantification (blue and red circles) on the skeletonized vascular network (green lines)
IMG/imageTB2.jpg
Figure 3. Measurements and estimated outputs for control and treated batches. Input signals and residuals are respectively plotted above and below
IMG/imageTB3A.jpg
Figure 4. Parameter estimates and coefficients of variation cv for control and treated batches
IMG/imageTB3B.jpg


previous Previous | up Home | Next next